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A double-blind, placebo-controlled study (N=366) appearing in the on-line New England Journal of Medicine reports that, as an adjunct to mood stabilizers, anti-depressants added no more benefit than a placebo to people diagnosed with bipolar disorder. Work was conducted by a consortium of medical schools in the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD), sponsored by the National Institute of Mental Health.

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