Read Genes and Circuitry, Not Just Clinical Observation, to Guide Classification for Research about the overlap of depression and bipolar disorder on Chromosome 3, one of the many genes researchers believe will one day influence classification, diagnosis and treatment.
The NIMH article that speaks to this most directly is: http://www.nimh.nih.gov/science-news/2010/same-genes-suspected-in-both-depression-and-bipolar-illness.shtml
Science Update January 28, 2010 Same Genes Suspected in Both Depression and Bipolar Illness
Increased Risk May Stem From Variation in Gene On/Off Switch
From the article:
"Our results support the growing view that there aren't common genes with large effects that confer increased risk for mood disorders," said McMahon. "If there were, in this largest sample to date, we would have found them. The disorders likely involve many genes with small effects — and different genes in different families — complicating the search. Rarer genes with large effects may also exist."
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